Platelet Disorders Crossword

IgG coat and damage platelets which are then removed by splenic macrophages
Lack of functional ADAMTS13, ultralarge vWF multimers build up
ITP is typically proceeded by _________ and is usually self limited
Petechiae and ecchymosis on skin, minimal bleeding despite ext. low platelets, bleeding of mucous membranes, no splenomegaly
Chronic form if ITP are most commonly in ______ 20 to 40 years of age
Treatment of ITP include corticosteroids, _______ or splenectomy for chronic ITP. Can also use romipolostim and eltrombogap for splenectomy resistant ITP
_____ cleaves von Hillebrand factor
These occlude small vessels in TTP leading to microangiopathic hemolytic anemia.
This is a life threatening emergency
Features of TTP include hemolytic anemia, ____ acute renal failure, fever, and fluctuating transient neuro signs
Treatment of TTP is ____ as soon as diagnosis is established
_____ are contraindicated in TTP
Heparin induced thrombocytopenia occurs when antibodies are formed against heparin platelet____ ______ complex
_______ heparin has a much lower risk of HIT
In HIT, platelets aggregate leading to what?
Decrease in platelet counts by what suggests HIT?
Antiplatelet factor IV antibody or serotonin release assay is the diagnostic test for what?
Inheritance of Bernard- Soulier Syndrome and Glanzmann Thrombasthenia?
Bernard-Soulier syndrome is a disorder of platelet adhesion to what?
Deficiency of platelet glycoprotein GP1b-1X is what disease?
Disorder of platelet aggregation due to deficiency in platelet glycoprotein GPIIb-IIIA?