Duchenne's Muscular Dystrophy Crossword

In terms of genetics, this is an _____ disorder
If untreated, you will be bound to this maneuvering device by age 12.
Muscular ________ is a group of diseases that DMD alls under.
The disease may present in a gross delay of this type of function
These levels should always be performed to investigate gross motor delay.
DMD is characterized by weakness in this region
A verb that many boys with DMD may never be able to do
Chronic respiratory insufficiency is secondary to this restrictive disease
This Orthopaedic complication develops in boys that do not receive corticosteroid treatment.
DMD patients may have an increased risk of malignant _______ if they are exposed to inhalational anaesthetics
Cause by mutation in this gene
What protein is encoded by the DMD gene
This type of deletion mutation predominates in DMD
These levels are raised 10-20 times in DMD
When genetic testing is negative this is performed on the muscle.
In DMD, absence of dystrophin may be almost ______.
Majority of female carriers are this.
Pharmacologic agent with proof of effectiveness in DMD.
one of the two Corticosteroid agents that is used most commonly.
Year frequency that that echocardiogram should occur from diagnosis until age 10.
This helps prevent progression or development of contractures. Used nightly.
This requires maintenance to prevent fractures
These issues may be a problem in DND, and are exacerbated by corticosteroids.
Function tests that should begin at 5-6 years old.
This type of counseling is offered for families with a male affected by DMD
This type of screening is available and recommended for carrier females.
The standard if care involes using corticosteroids to control ______.
Largest Gene in the human genome.
The DMD gene is on which part of the X-chromosome?
DMD mutations that partially diminish function gives rise to this disease.
Most RNA splicing occurs via which spliceosome?
There are 58 known _____ that arise from mutations within DMD gene
DMD causes abnormalities in this, also known as a persons manner of walking.
For children with DMD CLCC _____ as age increases.
Inevitable cause of death in untreated DMD patients that occur in heart and lungs.
DMD is ________. This means the conditions continues to worsen.
In DMD ambulation is lost early in the _______ decade.
An associated complication of Duchenne’s Muscular Dystrophy that requires surveillance.
Later stages of DMD involves distal muscles and upper ____.
Boys with DMD were proven to have a higher incidence rate of this chronic condition.
Dystrophin localizes to this part of the plasma membrane of the skeletal muscle.
One third of DMD mutations occur _____.
DMD intragenic deletions usually occur in a “_____” region.
Muscle weakness in 20% of carrier women.
Anesthetic agent contraindicated in boys that have Duchenne’s Muscular Dystrophy.
_______ muscle relaxants are contraindicated in boys with DMD.
Investigation of choice for suspected DMD in a boy.
Corticosteroid therapy in the long term prolongs _______.
Administration of succinylcholine in a DMD patient has a potential for _________.
One of the gold standards for DMD diagnosis.