Omeprazole Crossword

Omeprazole was first discovered in the late…
Now merged with a British company known as Zeneca, what Swedish company discover Omeprazole?
It was not until 1989, omeprazole was launched to the UK population. Omeprazole was the first…
Although Omeprazole can be sold in non-proprietary (generic) form. There are 3 companies in the UK that manufacture omeprazole: Mepradec (Discovery Pharmaceuticals), Losec MUPS (Astra Zeneca) and… (By Sandoz Ltd)
All forms Omeprazole requires a… to be obtained from a pharmacy.
Omeprazole can be distributed in the form of a… tablet and capsule.
Gastro-resistant tablets have a coating, that in acid does not…
There are … capsules and tablets sold in 10mg and 20mg
There are 7 capsules and tablets sold in…
Despite being in capsules and tablets, they can be administered as an…
An Omeprazole molecule contains Oxygen, Nitrogen, Sulphur and…
Omeprazole has a log P of 2. Log P represents the permeability of the drug to pass through the… membrane of cells and the ability to bind to their targets.
A characteristic of a molecule that determines its permeability to the cell
A low Log P means the molecule is…
The Log P being around 2 means it would have side effects to the… causing side effects such as dizziness, a common side effect for omeprazole.
Omeprazole has an efficient oral bioavailability according to the… Rule of Five. This is because the omeprazole molecular weight is less than 500, The log P is also less than 5. There are no more than 5 Hydrogen bond donors and there are no more than 10 hydrogen bond acceptors.
Omeprazole has a 1 HBD, and…
The rings formed in the molecule produce fixed bonds creating…
There is some... between the oxygen in the S=O and the hydrogen in the C-H connected to the benzene ring.
A low pKa means an increase electronegativity and an increase in the… . Omeprazole has a pKa of 4, this is because of the fact that it would be operating in a highly acidic environment in the stomach cells.
Omeprazole inhibits the secretion of… by irreversibly blocking enzymes of H+, K+-ATPase.
The proton pumps are found in the lining of stomach, the gastric parietal cells. It pumps the H+ into the lumen, by exchanging Hydrogen ions for… ions
This Indication causes inflammation that may damage tissue in the muscular tube that transports food from the mouth to the stomach, making it difficult to swallow food, and painful…
The indications for omeprazole are for Helicobacter pylori eradication in combination with other drugs. Benign gastric…
Common side effects of Omeprazole are abdominal pain, insomnia, nausea, skin reactions, vomiting and…
The Rare or Very Rare Side effects stated on the BNF 78 are Aggression, agitation, bronchospasm, encephalopathy, gastrointestinal candidiasis and…
There number of contraindications stated on the BNF for Omeprazole is…