Respiratory drug delivery Crossword

Ultrafine particles settle under ______ motion
Side effects from inhaled therapy could arise when particles are ______
A type of inhaler device.
pMDIs contain a ______ liquid inside a canister.
Alveolar macrophages are involved in the ______of foreign particles.
A drug used to relieve an asthma attack.
Salbutamol is an example of a ______ drug.
Present in a pMDI formulation is the largest quantity.
Was marketed by Pfizer as an insulin inhaler before being discontinued.
An excipient commonly used in DPI formulations.
The biggest challenge when using pMDIs is the ability to achieve ______
Is used to eliminate the need to coordinate breathing and actuation when inhaling through a pMDI.
Large particles are deposited in the respiratory tract by inertial ______
Particles are deposited by ______ in the airways when air velocity is relatively low
______ is the main mechanism of particle deposition in small airways and lung periphery.
The ______ is responsible for gas exchange.
The diameter of a sphere of unit density that has the same settling velocity in air as the arsenal particle in question.
______ clearance limits drug retention in the respiratory system.
Both pulmonary and nasal drug delivery routes belong to the ______ drug delivery route.
Is about 15-22 mm in diameter.
Can lead to narrowing of airways.
The ______ beat 10 times each second.
The nasal cavity is composed of inferior, middle and posterior ______
Inhaled particles may be cleared by an alveolar ______
______ drug delivery uses the inhaled route of drug delivery.
Administering drugs to the nose is referred to as ______ drug delivery.
Pulmonary drug delivery targets the ______
An advantage of the respiratory route of drug delivery is that it is ______
______ volume is the amount of air which enters the lungs during normal inhalation at rest.
Breath ______ for a few seconds allows particles to settle in the airways under gravity.
Sedimentation is a particle deposition mechanism that occurs because of the effect of ______
An aerosol is a two-phase system defined as a dispersion or suspension of ______ particles or liquid droplets in a gaseous medium.
An advantage of nasal drug delivery is the presence of a rich ______ supply in the nose.
An advantage of pulmonary drug delivery is the ability to achieve a rapid ______ of action.
DPI stands for: dry ______ inhaler.
Inhaled particles avoid ______ metabolism.