Parkinson's Disease Crossword

Second most common neurodegenerative disease
This phenomenon is a gradual worsening of Parkinsonian symptoms as a patient's medications begin to lose their effectiveness (Hyphenated)
One of the four classic symptoms of Parkinson's disease
Destruction of this part of the brain by Parkinson's disease leads to dopamine depletion (2 words)
An inhibitory neurotransmitter
Abnormal muscle tone leading to impaired or abnormal movements
Type of rigidity seen in Parkinson's disease
Type of tremor seen mostly at rest and less severe during voluntary activity (2 words)
An excitatory neurotransmitter
An example of an indirect-acting dopamine receptor agonist
An irregular, spasmodic, involuntary movements of the limbs or facial muscles
Drugs that exert their antiparkinson effects before the nerve synapse
How many millions of Americans are affected by Parkinson's disease?
Mean age of onset of Parkinson's disease (2 words)
Enzyme that causes breakdown of catecholamines in the body (2 words)
A major effect of nonselective MAOIs when they interact with tyramine-containing foods (2 words)
One drug under catechol ortho-methyltransferase (COMT) inhibitors category
An antiviral drug considered a dopamine modulator that is also indicated for treatment of moderate Parkinson's disease
A drug under ergot direct-acting dopamine receptor agonist
Slowness of movement
Newest antiparkinson drug approved by FDA in 2008
This COMT drug is contraindicated in liver failure
One example of newer nonergot nondopamine dopamine receptor agonists
The biologic precursor of dopamine that can penetrate into the CNS
A peripheral decarboxylase inhibitor used in combination with levodopa to reduce adverse effects of levodopa
An anticholinergic drug used for Parkinso's disease
Levodopa and carbidopa are both contraindicated in this type of glaucoma (2 words hyphenated)
Symptoms of Parkinson's disease do not appear until how many percent of dopamine in the substantia nigra has been depleted?
Absence of psychomotor activity resulting in mask-like facial expression
Shakiness of the extremities seen mostly at rest