Clostridium difficile Crossword

Highly resistant dormant form of vegetative bacteria
Gram ___ have a thick peptidoglycan layer
Rod shaped characteristic for bacteria
Grows in absence of oxygen
Hospital acquired sickness
Natural protective barrier found in the intestine
Substance in intestine that affect growth of C. difficile
C. difficile makes ___ types of toxins
False membrane that contains destroyed fibrin, neutrophils, and intestinal cells
Toxins A and B inactivates ___ GTPases
Potent inflammatory toxin
Most commonly infiltrated colon segment
Alcohol-based hand hygiene products are ____ when preventing spores
Low cost and easy to use, but needs other tests
Detection of ___ identifies C. difficile antigens
Antibiotic used to treat non-severe infection
Antibiotic to treat severe infection
___ transplantation have the highest rate to prevent recurring infection
Reduces risk of C. difficile infection
Most common symptom
Infected majority presents as ___
C. difficile has been assigned to the ___ family in the latest taxonomic reviews
Have at least ___ phylogenetic clades
Genes for toxins A and B are encoded on the ___ Locus (PaLoc)
There are three ___ genes on the PaLoc to regulate and release toxin
Colonizes in the ___ intestines
Binary toxin ___ virulence
Disrupts natural microflora in the gut
The ___ gender have higher tendency to contract illness from C. difficile
People with low antitoxin A ___ were likely to die during the first 30 days of infection
Inhibitory gene ___ increase toxin A and B production
Toxic ___ is one form of clinical presentation
Toxins found in ___ help diagnose C. difficile infections
Spread of species is through ___-oral route by ingesting its spores
Toxins A and B causes ___ reactions in the body
Community cases tends to infect ___ people
Hospital cases tends to infect ___ people
Strains can be differentiated by different ___ techniques
Uses the 16S-23S intergenic spacer region in rRNA gene complex to differentiated strains
This regulator controls the transition from bacterium to spore form
Asymptomatic carriers show great ___ immune response against the toxins
___ gene transfer of PaLoc can cause nontoxigenic strains to produce toxins
Only ___ strains cause illness in humans
This algorithm improves diagnostic sensitivity and specificity
Antibiotics that treat broad illness ___ induction rate compared to other antibiotics
PaLoc lacks any known ___ genes and repeats at its borders
Expression of LCT (large clostridial toxin family) is regulated by ___ locus
First isolated from healthy ___ stool
Spores are ___ to heat, acid, and antibiotics
Antibiotic not widely accepted but is associated with lower recurrence rate in patients